Mesenchymal Stem Cells in the Treatment of Human Diseases: Molecular Mechanisms and Clinical Studies

Who conducted the study and which universities were involved

The study was conducted by a large Chinese research team. Authors: Xia Han, Rongdong Liao, Xiang Li, Cantong Zhang, Shaochuan Huo, Lei Qin, Yi Xiong, Tailin He, Guozhi Xiao, and Tianfeng Zhang.

No single university was involved—several medical and research centers participated, including Guangzhou University of Chinese Medicine, Southern Medical University, Guizhou Medical University, Shenzhen University Medical School, Southern University of Science and Technology (SUSTech), and the Chinese Academy of Sciences.

What They Studied

The authors compiled current data on how mesenchymal stromal/stem cells (MSCs) potentially act in various diseases and what results have already been obtained in preclinical and clinical studies. The review covers autoimmune and inflammatory diseases, neurodegenerative conditions, orthopedic diseases, and other areas.

The authors provide a detailed examination of the secretion by cells of growth factors, cytokines, and extracellular vesicles, which are involved in intercellular communication, immune regulation, angiogenesis, cell survival, and tissue repair processes. The interaction of MSCs with T cells, B cells, dendritic cells, and macrophages is also described.

Journal: Signal Transduction and Targeted Therapy (Nature Portfolio)

Year: 2025, Volume 10, Article 262

Type: Review Article — a comprehensive scientific review.