Exosomes in Aging and Age-Related Disorders: Mechanisms, Therapeutic Potential, and Challenges

Who conducted the study and which university

The authors are Sahar Safaei, Sepideh Sohrabi, Pouya Zahmatkesh, Mohammad Sadegh Soltani-Zangbar, and Leili Aghebati Maleki.

All authors are affiliated with the Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

What was studied

The authors analyzed current data on the role exosomes play in aging processes and age-related diseases. Exosomes are considered carriers of proteins, lipids, mRNA, and microRNA between cells, through which they can influence inflammation, the immune response, cellular aging, and tissue repair.

MSC-derived exosomes are discussed separately. In preclinical studies, they have demonstrated potential anti-inflammatory, antioxidant, and regenerative effects. The authors discuss their application in research on Alzheimer’s disease, Parkinson’s disease, osteoarthritis, osteoporosis, sarcopenia, and other age-related conditions.

Journal: Journal of Translational Medicine

Year: 2025

DOI: 10.1186/s12967-025-07379-1

Type: Research Review.